Which of the following chemotherapeutic drugs is associated with this characteristic rash?

a.Cyclophosphamide

b.Bleomycin

c.Capecitabine

d.Liposomal Doxorubicin

Answer:

b.Bleomycin

Explanation:

This is a characteristic rash induced by Bleomycin. This is aptly named as Whiplash rash or flagellate hyperpigmentation on account of its characteristic appearance.20% of the patients receiving the drug develop skin hyperpigmentation. Its a non pruritic rash and fades over time after cessation of chemotherapy.Skin and lungs lack the enzyme Bleomycin hydrolase (Cysteine protease) which accounts for the increased toxicity in these organs

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